Cancer mostly genetic, Archive issue | RJME

cancer mostly genetic

Do we know enough about the genetic involvement in laryngeal cancer susceptibility and prognostic outcome? Corina Iulia Cornean, Marcel Cosgarea, Andreea Catana, Carmen Aurelia Mogoanta, Violeta Necula, Alma Aurelia Maniu Introduction: Advances in molecular biology have opened the door to a wide range of research material through the usage of genetic testing on certain variables within the human genome known as single-nucleotide polymorphisms SNPs.

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The purpose of this article is to present a review on the influence variants within SNPs have on the outcome of laryngeal cancer when associated with different variables, such as external toxins or survival rate. Amongst these toxins, cancer mostly genetic most frequent and most studied have been alcohol and tobacco consumption, with a proven increased rate of overall cancer risk within the aero-digestive tract. Materials and Methods: The review was realized utilizing available studies on the subject of genetic polymorphisms analysis of deoxyribonucleic acid DNA samples using polymerase chain reaction PCR assays and laryngeal cancer published in the PubMed database.

Results: Statistical analysis of polymorphisms shows cancer mostly genetic cancer mostly genetic positive association between two genetic variants of the human genome mutant homozygote and heterozygote and cancer risk with significant influence on patient outcome and survival.

Genotype combinations were divided into two categories depending on the individual at risk and protective allele within the loci of each inherited gene block.

Amongst the genes involved with aero-digestive cancers, the most studied were those belonging to the xenobiotic metabolism, nucleotide excision repair NER and DNA repair pathways.

The presence of toxins has a distinct cumulative effect within the genotype-phenotype relationship, which further influences the presence of malignancy depending on the adaptability of each individual genome.

Conclusions: Laryngeal cancer evolution is linked to inherited risk factors found within the genetic code.

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Most studied were the genes belonging to NER pathways, DNA repair and xenobiotic metabolism, which all favored mutant homozygote and heterozygote variants, as high risk factors. Only five articles focused on overall survival rates with insufficient results to undisputedly predict the risk variants.

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The consumption of external toxins has a positive effect on the overall cancer risk in consumers. Most articles affirmed further evaluation or replication was needed in a larger scale population to conclusively validate their results.

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PDF 2. The heritable MTC results from a germline mutation in the rearranged during transfection RET cancer mostly genetic and is included into the multiple endocrine neoplasia 2 MEN2being associated with other endocrine abnormalities and clinical features.

MTC is a neuroendocrine tumor cancer mostly genetic releases a wide range of secretory products that are responsible for a variety of symptoms, making it difficult to be diagnosed. For this reason, the pathological analysis is of vital importance to ensure that the correct diagnosis is made. This review presents the main data from the contemporary literature related to the pathological diagnosis of a patient with MTC and highlights the wide range of tumor cytological features, the many histological variants, as well as the particular tumor immunophenotype.

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Antiplatelet therapy in secondary ischemic stroke prevention - a short review Cristina Florescu, Edme Roxana Mustafa, Elena-Anca Tartea, Diana-Ruxandra Florescu, Valeria-Carmen Albu Platelets play an essential role in atherothrombosis and for this reason they are the primary target of antithrombotic therapy in ischemic stroke. We discussed here the evidence for efficacy and safety of current knowledge in antiplatelet therapy for stroke prevention after an acute ischemic stroke or transient ischemic attack.

After an acute episode, long-term antithrombotic therapy is essential for the secondary prevention of stroke recurrence and complications. These are aspirin, clopidogrel and dipyridamole.

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All of these antiplatelet therapies, besides inhibiting acute arterial thrombosis, also interfere with physiological hemostasis. In conclusion, we can say that current recommendations focused primarily cancer mostly genetic the therapy with aspirin for the secondary prevention of stroke in patients that presented vascular events, such as ischemic stroke of non-cardioembolic cause or transient ischemic attack and, as appropriate, aspirin plus dipyridamol or clopidogrel.

The new therapy with ticagrelor in secondary stroke prevention seems to be promising, but more randomized clinical trials are needed to accurately assess the safety and efficacy of this new antiplatelet drug.

Current understanding of psycho-neurobiology in depressive disorders with suicidal thoughts - translational models Eduard Nicusor Bondoc, Dragos Marinescu, Ileana Marinescu, Ramona Denise Malin, Liliana Stanca, Roxana Eugenia Zavoi Epidemiological data confirm the rising incidence of depression associated with cancer mostly genetic ideation and cardiovascular comorbidities of coronary type.

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In contradiction with the large number of antidepressant drugs, the therapeutic results are not satisfactory, with numerous existing incomplete remissions characterized by maintained cellular dysfunctionalities that amplify the cognitive deterioration and the risk of several somatic comorbidities. The surprising fact is the relatively high number of deaths in this type of patients due to acute coronary disease myocardial infarction - MI.

The vulnerability of hippocampal and frontal cortex cerebral structures is presented as obtained on animal model consecutive to hypothalamic-pituitary-adrenal HPA axis hyperactivity and on theoretical model where the hypothalamic disconnectivity determines the activation in the sympathetic autonomic nervous system, leading to heart disorders: high blood pressure, left ventricular hypertrophy and coronary illness.

Identifying the association of psychological risk factors, patients fitting in a model of psychosomatic dominant personality traits, where the main risk factors cancer mostly genetic represented by inflexibility, guilt and self-accusation feelings, associated with increase of biological indicators proinflammatory factors, endothelial dysfunction and cytokine aggressiveness and neuroimaging indicators frontal, temporal, hippocampal atrophy, ventriculomegaly, cerebellum atrophy.

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Changes identified post-mortem in the arterioles from the frontal cortex were found also in the coronary vessels, suggesting a symmetric evolution The highlighted personality factors are responsible for the decrease of adherence and compliance both in the psychiatric and the cardiologic treatment, the patient being exposed to behavioral risks regarding life style and nutrition, factors that increase the risk for acute coronary accident.

The psycho-neurobiological inspired theoretical models argument the importance of a differentiated and customized approach of the patients with depressive disorder and suicidal ideation, and they can be the base for initiating strategies for prevention of unfavorable evolution and risk of death by MI. Due to the rich oro-maxillofacial vasculature and the fact that some dental procedures may cause a bleeding, the physician should be able to correlate this risk with the hemorrhagic risk.

Dental procedures are a trigger for psychic stress. One of the cancer mostly genetic important changes in acute stress is in cardiovascular system.

Este o boală genetică It's a genetic disorder - Pretty terrible from what I understand. Complexul Carney: o boală genetică care poate crește riscul unei tumori a glandei pituitare.

In healthy patients, these changes are reversible and have no significant consequences, but in patients with cardiovascular diseases, the response to the catecholamine stress can cause organic lesions resulting in an acute myocardial infarction or stroke. This review explores in a concise manner the biochemical changes concerning anticoagulation and thrombolytic treatment in dental procedures.

This method of treatment was discovered when primitive Chinese people discovered that pain in one part of the body can be alleviated if it stings in a particular area of the body.

Acupuncture has achieved to a climax in Ming Dynasty A. Yang Jizhou compiled a book that presents a complete and laborious description of the meridians, collaterals, acupuncture points, manipulating methods of acupuncture and their indications. According to the ancient description of the meridians and collaterals and the research on the anatomy of Western medicine, some scholars think the meridians and collaterals are closely related to the blood vessels.

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In recent years, many reports have showed that acupuncture has remarkable effect on the pituitary gland and adrenal cortex system, the sympathetic nerve and adrenal medulla system, the pituitary gland and thyroid gland system, the sexual glands, and the posterior pituitary system. Thus, some researchers put forth the theory of the meridians and collaterals associated with regulatory function of the neurohumoral system, and the action cancer mostly genetic acupuncture and moxibustion is brought about by the way of the nerves and body fluid.

This condition is accompanied by a strong symptomatology, which has induced intense research on this topic.

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From a morphological point of view, it is represented by the existence of endometrial glands and, sometimes, of the periglandular stroma endometriosis in the structure of the myometrium, at a significant distance from the normal endometrium. Various inflammatory, vascular and mechanical factors accentuate the symptoms and evolution of this pathology. Our study included a total number of 32 patients, eight cases for each of the following histopathological subtypes: endometrium - proliferative phase, endometrium - secretory phase, myometrium with endometrial glands adenomyosisand myometrium with hyperplastic transformation of endometrial glands hyperplastic adenomyosisrespectively.

We have conducted clinical, morphological and morphopathological studies of the structures in question.

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The interesting aspect of this study is the technique of simultaneously labeling of cancer mostly genetic inflammatory, vascular and epithelial elements. Changes in EpCAM expression are reported in several malignancies, as an early indicator for carcinogenesis.

Our study aimed to evaluate the EpCAM expression in different subtypes of papillary thyroid carcinoma PTCfocusing on its role in the risk stratification of the histological helminth ou slăbire medicament and its relationship with the classical clinico-pathological characteristics.

Arnold Graffi, eminent physician and cancer researcher, died in Berlin on Monday, January 30, at the age of 95 following a long illness as announced by his family. Professor Graffi contributed significantly to the understanding of the development of cancer.

We analyzed 70 selected cases of PTC, divided into low- and high-risk groups, according to histological criteria. MOC expression was assessed at the membrane and cytoplasmic levels, using a semi-quantitative score that allowed the classification in low- and high-score category, respectively. The relationship between MOC expression and clinico-pathological characteristics was statistically evaluated.

We found statistically significant correlation between MOC expression low versus high and the risk groups, tumor size and tumor relapse.

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The modification of MOC location, with consequent changes in its interactions with other cell-adhesion molecules, is integrated in cancer mostly genetic carcinogenic mechanism. Our study demonstrates the large variability of MOC expression in PTC histological variants, and highlights the differences between the low and high MOC expression that could work as a useful tool for the identification of those high-risk PTC cases, with unfavorable clinical outcome.

Aquaporin 1 AQP1 is a membrane protein characteristic to epithelial and endothelial cell of the human body.

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The Pax family of genes encodes transcription factors with important role in intrauterine development. Connexins are transmembrane proteins found in gap junctions. Materials and Methods: We studied 34 cancer mostly genetic mortem fetuses of 9 to 24 weeks from the Laboratory of Pathology, Emergency County Hospital of Targu Mures, Romania, using immunohistochemistry.

Results: AQP1 expression appeared in the apical and basolateral parts of cells, lining the proximal convoluted tubules and the descending limb of Henle negii unei persoane din ce loop, then in the tubule pole of Bowman s capsule also.

Nuclear expression of PAX2 was observed in structures developed both from the ureteric bud and the metanephric mesenchyme, and of PAX8 was observed in the proximal convoluted tubule s epithelium, Henle s loop, and collecting ducts. Cytoplasmic expression of Cx36 was localized to nephrons in different developmental stages, glomerular vessels and collecting ducts, and of Cx43 was localized to the endothelium of glomerular and peritubular vessels, as well as to the epithelium of the proximal tubules.

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Discussions and Conclusions: Nephrogenesis begins in the embryonic period, and continues into cancer mostly genetic fetal period as well. It is regulated by a wide array of markers. The current study supplements literature data regarding immunoexpression of these markers during renal development in the fetal period. It is a medical condition related to the salivary glands, namely a benign cystic tumor which contains an epithelial component and an abundant lymphoid stroma.

It is also named Warthin tumor after Aldred Scott Warthin, the pathologist who described this entity in by observing it in two patients. Warthin tumor is a benign one and ranks secondly in terms of the most common not malignant salivary gland tumor located in the parotid gland. Because of its cystic nature, from the clinical point of view, it appears to be a cancer mostly genetic tumor often fluctuant on palpation. In terms of the treatment of choice, complete excision with wide tumor-free margins is preferred.

The aim of the present article is to evaluate possible correlations between detoxifiere organism copii features and postoperative complications in a target group made up of 10 patients diagnosed with Warthin tumor of the parotid gland admitted for surgery in a period of 21 years and to compare the results with literature.

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