Material and method: Sixty patients were included in our study. All of the patient underwent colposcopy-guided biopsy to asses the grade of CIN. For the immunohistochemistry exam we used p16INK4A and Ki antibody and their expression was semiquantitatively classified in 4 classes: 0, 1, 2 and 3.
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Results: 7 of our cases were benign Cancer burden in the year The global picture. Eur J Cancer ; 37 Suppl 8: S4 Estimates of cancer incidence and mortality in Europe in Eur J Cancer ; 99 Richart RM. A modified terminology for cervical intraepithelial neoplasia. Obstet Gynecol ; Ann Oncol ; 21 3 : Evaluation of p16INK4a and pRb expression detection of human papillomavirus type 16 integration cervical squamous and glandular neoplasia.
Hum Pathol ; 35 6 : Ki immunoquantitation in cervical intraepithelial neoplasia CIN : a sensitive marker for grading.
J Pathol ; Hum Pathol ; Expression of p16 and Ki in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection.
J Gynecol Oncol ; Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri.
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Int J Cancer ; J Clin Pathol ; Cancer Treat Rev ; 35 3 : Am J Surg Pathol ; 31 1 : P16INK4A Immunochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol ; 26 11 : Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica.
Cancer Epidemiol Biomarkers Prev ; Methods Mol Med ; 73 Kalof AN, Cooper K. Adv Anat Pathol ; J Pathol ; Evaluation of MIB-1 Positive cell clusters as a diagnostic marker for cervical intraepithelial neoplasia. Panjkoviæ M, Ivkoviæ-Kapicl T. Ki expression in squamous intraepithelial lesions of the uterine cervix.
Arch Oncol ; 14 12 : 23 Diagnostic accuracy of cervical low-grade squamous intraepithelial lesions is improved with MIB-1 immunostaining. Am J Surg Pathol ; 26 1 : Mehrotra A, Mati GM. Assessment of monoclonal antibody MIB-1 labeling indices in cervical intraepithelial lesions of the uterine cervix in paraffin section.
J Obstet Gynecol India ; 58 4 : Ki quantitative evaluation as a marker of cervical intraepithelial neoplasia and human papillomavirus infection.