Cancer ovarian prevention

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Could bilateral salpingectomy reduce the risk of ovarian cancer? Epithelial ovarian cancer is the fifth leading cause of cancer mortality among women. There is no effective screening for ovarian cancer in the current practice that could decrease its mortality.

Institute of Oncology Prof. Dr. Alexandru Trestioreanu, Romania

There is cancer ovarian prevention large volume of scientific proofs that prophylactic salpingectomy could give the clinicians the opportunity to prevent the cancer ovarian prevention of ovarian cancer.

The goal of our paper is to sensitize the gynecologic community and then to study in a prospective national trial the potential use of prophylactic bilateral salpingectomy as a primary preventive strategy of the ovarian cancer. Currently, we have no prospective evidence in order to analyze the effectiveness of prophylactic bilateral salpingectomy in preventing ovarian cancer.

Through this article, we intend to launch an invitation to all Romanian gynecologic surgery centers, to participate in a prospective study evaluating the effectiveness of bilateral salpingectomy in the prevention of ovarian cancer.

Materials and method.

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There is no strong evidence regarding the effectiveness of bilateral salpingectomy in cancer ovarian prevention prevention of ovarian cancer and this is the first multicenter, prospective trial in order to study this hypothesis. Using this journal and other media channels of the Romanian Society of Obstetrics and Gynecology, we want to invite national centers of obstetrics and gynecology to attend to our study.

The deadline for the approval is 1st of May cancer ovarian prevention The patients will be consecutively selected from a general population who undergo a surgical procedure during which the fallopian tubes could be removed in addition to the primary surgical procedure.

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All data needed regarding the patient and the procedure will be collected in an online document and kept into the database gastric cancer immunotherapy the department. The enrollment period cancer ovarian prevention be from 1st of June till May 30th Before 1st of August all the data must be collected and prepared for publication.

The effectiveness of bilateral salpingectomy in the prevention of ovarian cancer will be evaluated according to multiple variables. Keywords bilateral salpingectomy, ovarian cancer, ovarian cancer prevention Rezumat Introducere. Cancerul ovarian epitelial reprezintă a cincea cauză de mortalitate prin cancer în rândul femeilor. Nu există nicio metodă eficientă de screening pentru cancerul de ovar care să scadă mortalitatea.

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Salpingectomia profilactică poate oferi oportunitatea de prevenție a apariției cancerului ovarian. Studiul nostru are scopul de a invita comunitatea de specialitate în vederea participării la un trial prospectiv național, care să studieze rolul potențial al salpingectomiei bilaterale profilactice ca strategie de prevenție primară a cancerului ovarian.

În momentul actual, nu deținem date prospective care să analizeze eficacitatea salpingectomiei bilaterale profilactice ca metodă de prevenție a cancerului ovarian.

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Prin intermediul acestui articol, intenționăm să lansăm o invitație centrelor de chirurgie ginecologică din România pentru a participa la un studiu prospectiv care să evalueze eficacitatea salpingectomiei bilaterale în prevenția cancerului ovarian.

Materiale și metodă. Nu există evidențe valide cu privire la eficacitatea salpingectomiei bilaterale profilactice în prevenția cancerului ovarian, acesta reprezentând primul trial prospectiv, multicentric care studiază această ipoteză. Prin intermediul revistei, precum și al altor canale media ale Societății Române de Obstetrică și Ginecologie, intenționăm să invităm centrele naționale de obstetrică și ginecologie să participe la studiul nostru.

În unele cazuri, cancerele de colon pot cauza sângerări la nivelul tractului digesttiv, ceea ce duce la apariţia sângelui în fecale sau fecale de culoare închisă. Uneori cancerul poate bloca colonul, numită obstrucţie intestinală.

Toate centrele necesită avizul comisiei de etică, precum și aprobarea unui consimțământ informat adaptat studiului. Termenul stabilit pentru aprobare este 1 mai Selecția pacientelor se realizează din populația generală, paciente supuse unei proceduri chirurgicale, în timpul căreia se poate realiza cancer de prostata ministerio da saude bilaterală profilactică, adițional intervenției principale.

Toate datele vor fi colectate prin intermediul unui formular online și centralizate într-o cancer ovarian prevention de date. Perioada de înrolare a pacientelor va fi începând cu 1 iunie și până pe 30 mai Până pe 1 august toate datele trebuie centralizate și pregătite spre a fi publicate. Eficacitatea salpingectomiei bilaterale profilactice în prevenția cancerului ovarian va fi evaluată în funcție de mai multe variabile.

Cuvinte cheie salpingectomie bilaterală cancer ovarian prevenția cancerului ovarian Introduction Ovarian cancer has the poorest prognosis and limited options in terms of early diagnosis and efficient treatment. There are no effective screening methods to prevent ovarian cancer in order to decrease mortality rate. New theories in carcinogenesis suggest that ovarian high-grade serous carcinoma develops from the distal fallopian tube cancer ovarian prevention 1.

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Opportunistic bilateral salpingectomy during hysterectomy or other gynecological surgery has a minimal additional surgical risk to the patient. For this reasons, in our clinic we adopted this prophylactic surgical procedure in patients eligible for hysterectomy to treat benign conditions, with no complication or intraoperative incidences.

All the patients were counseled about the potential benefits of the removal of the fallopian tubes in order to decrease the risk of ovarian cancer. Morelli et al.

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A larger long-term study is needed to assess the prophylactic role of opportunistic bilateral salpingectomy and its implications in ovarian cancer development. Materials and method We propose a national, multicenter, prospective, descriptive non-randomized interventional trial in order to evaluate the prophylactic role of opportunistic bilateral salpingectomy in reducing the risk of developing ovarian carcinoma. The aim of our multicenter trial is to analyze the potential use of bilateral salpingectomy as a primary preventive strategy of the ovarian cancer.

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The study will be in accordance with the Committee on Publication Ethics guidelines and will be approved by the institutional review board of each hospital that will join the project. Each patient who will participate in this study will be well informed regarding the procedures and will sign a consent form for data collection for research purposes.

An independent data safety and monitoring committee will evaluate the cancer ovarian prevention cancer ovarian prevention the study.

All women candidates for different surgical gynecological interventions for benign reasons hysterectomy, ovarian cystectomy, tubal ligation or caesarean section, with requested voluntary tubal ligation, will be enrolled after a previous counseling with the potential benefits and fertility consequence of the method. After bilateral salpingectomy, all women will perform clinical and transvaginal ultrasound examination annually for 3 consecutive years.

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All data regarding the cancer ovarian prevention and the procedure will be collected in a document in the D-Base designed for this purpose. We will exclude from the enrollment women with malignant and borderline diseases, even in cases when the diagnosis was established intraoperatively or later histopathological specimen. Also, will be excluded patients that do not agree to sign the informed consent.

The enrollment period will start on the 1st of June till 30th of May Outcomes Before the end of July all the data must be collected and prepared for publication. The effectiveness of bilateral salpingectomy in the prevention of ovarian cancer will be evaluated according to multiple variables taken into consideration.

Discussion cancer ovarian prevention conclusions Ovarian cancer is an aggressive gynecologic cancer, representing the fifth leading cause of cancer deaths among women, and has no valid screening methods 4. Cancer ovarian prevention serous cancer ovarian prevention carcinoma is the most common and aggressive subtype, with poor prognosis and low survival rate 7.

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InVenturella et al. The study of Morelli et al.

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To our knowledge, there are poor cancer ovarian prevention and epidemiological data about ovarian cancer prevention and screening, and the prophylactic bilateral salpingectomy remains an accessible method with minimal risks that could be detoxifiere fata by gynecologists. Another option in the prevention of ovarian cancer would be bilateral salpingectomy in high-risk population in order to maximize their benefit 9.

Traditionally, the ovarian tissue was regarded as the most common primary site of cancer ovarian prevention, but the new studies suggest that this process starts in the distal fimbria and then spread to the ovary.

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According to the new theories, we can consider the epithelial carcinoma of the ovary, the fallopian tubes and peritoneum as a single entity 2.

For accurate data, we need long-term studies to determine the efficacy of opportunistic bilateral salpingectomy for ovarian cancer prevention.

Bibliografie 1. The distal fallopian tube: a new model for pelvic serous carcinogenesis. Curr Opin Obstet Gynecol. Opportunistic salpingectomy for ovarian, fallopian tubal, and peritoneal carcinoma risk reduction.

[Expression of CA-125 in ovarian cancer].

Prophylactic salpingectomy in premenopausal low-risk women for ovarian cancer: primum non nocere. Gynecol Oncol ; — Committee Opinion. Salpingectomy for ovarian cancer prevention noJan Soslow RA. Histologic subtypes of ovarian carcinoma: an overview. Int J Gynecol Pathol ; McCluggage WG. Morphological subtypes of ovarian carcinoma: a review with emphasis on new development and pathogenesis.

Pathology, ; Why have ovarian cancer mortality rates declined? Part I. Gynecol Oncol, ; 3 —9. Wide excision of soft tissues adjacent to the ovary and fallopian tube does not impair the ovarian reserve in women undergoing cancer ovarian prevention bilateral salpingectomy: results from a randomized, controlled trial.

Poate salpingectomia bilaterală reduce riscul de cancer ovarian?

Fertil Steril. Schenberg T, Mitchell G. Prophylactic bilateral salpingectomy as a prevention strategy in women at high-risk of ovarian cancer: a mini-review, Front Oncol, ; Articole din ediţiile anterioare Tumorile cordoanelor sexuale stromale ale ovarului: tumoarea de granuloasă.

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